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Caribbean
The Caribbean is the single most popular cruise region in the world by passenger volume, with the Cruise Lines International Association consistently reporting that it captures the largest share of global cruise itineraries, driven substantially by its position within easy sailing distance of major US departure ports including Miami, Fort Lauderdale, and Port Canaveral. The region's cruise industry has grown to the point that several cruise lines now operate private or semi-private islands specifically for their own passengers, including Royal Caribbean's Perfect Day at CocoCay and Disney's Castaway Cay, giving cruise lines direct control over an entire day's shore experience rather than relying solely on public island ports. Caribbean itineraries typically fall into "Eastern," "Western," and "Southern" routing categories, each visiting a different cluster of islands — from Puerto Rico and the US Virgin Islands in the east to Cozumel and the Cayman Islands in the west — giving repeat cruisers meaningfully different itineraries even within the same broader region. The Caribbean's combination of its position as the world's single most popular cruise region, cruise-line-owned private island destinations, and distinct eastern, western, and southern itinerary routes has made it the default entry point for the large majority of first-time cruise passengers in North America.
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Antarctica
Antarctica cruises depart almost exclusively from Ushuaia, Argentina, the southernmost city in the world, crossing the notoriously rough Drake Passage — roughly 500 miles of open ocean between South America and the Antarctic Peninsula — a crossing serious enough that most expedition ships are specifically ice-strengthened and built for the conditions. Unlike conventional cruises, most Antarctic voyages are operated as genuine expedition cruises, using smaller ships carrying a few hundred passengers or fewer specifically to comply with Antarctic Treaty regulations limiting the number of people allowed ashore at any single landing site at one time, a restriction designed to minimize human impact on the fragile ecosystem. The continent's wildlife, including multiple penguin species, seals, and whales, shows minimal fear of humans due to the near-total absence of natural land predators and limited historical human contact, letting expedition passengers observe animals at close range during guided zodiac landings on the ice and rocky shoreline. Antarctica's combination of its remote Drake Passage crossing, strict expedition-style visitor limits mandated by international treaty, and its uniquely approachable wildlife has made it one of the most logistically demanding and increasingly sought-after cruise destinations for experienced travelers seeking a genuinely different kind of trip.
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