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Walgreens
Walgreens was founded in 1901 in Chicago by Charles R. Walgreen Sr., who purchased the drugstore where he had previously worked as a pharmacist, and the company grew over the following century into one of the largest pharmacy chains in American history. The company is widely credited with popularizing the malted milkshake in the 1920s at its in-store soda fountains, a feature that became a defining part of the classic American drugstore experience for decades before being phased out of most locations. Walgreens merged with European pharmacy and health retail giant Alliance Boots in 2014 to form Walgreens Boots Alliance, creating one of the largest pharmacy-led health and wellness companies in the world with a footprint spanning multiple continents. Walgreens's combination of its century-plus American drugstore heritage, including its role popularizing the soda-fountain milkshake, and its transformative merger with Alliance Boots has made it one of the most globally significant pharmacy chains in the industry.
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Costco Pharmacy
Costco Pharmacy operates inside the company's membership warehouse club locations, and unlike most Costco departments, prescription pharmacy purchases and consultations are legally required to be available to non-members as well, since pharmacy access cannot be restricted by membership under federal and state regulations in most areas. The pharmacy built a reputation for competitive prescription pricing, benefiting from Costco's broader business model of prioritizing high sales volume and low markups over per-item profit margin, an approach the company applies across its general merchandise as well. Costco Pharmacy has consistently ranked highly in customer satisfaction surveys covering pharmacy services, frequently cited for lower out-of-pocket prescription costs compared to dedicated pharmacy chains, particularly for cash-paying customers without insurance coverage. Costco Pharmacy's combination of its unusual open-to-non-members legal structure and its consistently strong customer satisfaction rankings has made it one of the most distinctively positioned pharmacy operations in American retail.
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